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CORRELATION BETWEEN GANGLIOSIDE DISTRIBUTION AND HISTOLOGICAL GRADING OF HUMAN ASTROCYTOMAS
Author(s) -
BERRA Bruno,
GAINI Sergio M.,
RIBONI Laura
Publication year - 1985
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.1985.36.3.363
Subject(s) - ganglioside , grading (engineering) , malignancy , pathology , correlation , astrocytoma , medicine , biology , glioma , cancer research , biochemistry , mathematics , ecology , geometry
Changes in membrane lipid content and composition have been repeatedly detected in experimentally induced as well as spontaneous tumors. Previous data on ganglioside analysis in human astrocytomas suggested a possible correlation between their content and pattern and the histological grading of these tumors. In our study we could definitely prove this correlation: in fact the level of malignancy, passing from grade 1 to grade IV, is associated with a statistically significant increase of a ganglioside identified as ganglioside GD 3 . Another important modification in the ganglioside pattern of human astrocytomas is the decrease in polysialylated species with increasing level of malignancy.