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A 14;19 TRANSLOCATION IN B‐CELL CHRONIC LYMPHOCYTIC LEUKEMIA: A NEW RECURRING CHROMOSOME ABERRATION
Author(s) -
UESHIMA Yoshimi,
BIRD Mary Lourdes,
VARDIMAN James W.,
ROWLEY Janet D.
Publication year - 1985
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.1985.36.3.287
Subject(s) - chromosomal translocation , prolymphocytic leukemia , chronic lymphocytic leukemia , chromosome analysis , cytogenetics , chromosome , leukemia , medicine , cancer research , biology , pathology , karyotype , immunology , genetics , gene
Four of 30 patients with a diagnosis of B‐CLL or prolymphocytic transformation of CLL, who had an adequate cytogenetic analysis, had abnormalities involving 14q32. Three of the 4 had a translocation involving chr. 19; in 2 of them it appeared to be t(14;19) (q32;q13‐1). The third patient probably had the same translocation. All 3 patients had received therapy prior to cytogenetic analysis.