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Comparative analysis of the NF2, TP53, PTEN, KRAS, NRAS and HRAS genes in sporadic and radiation‐induced human meningiomas
Author(s) -
Joachim Thomas,
Ram Zvi,
Rappaport Zvi H.,
Simon Matthias,
Schramm Johannes,
Wiestler Otmar D.,
von Deimling Andreas
Publication year - 2001
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.1467
Subject(s) - hras , neuroblastoma ras viral oncogene homolog , pten , kras , meningioma , cancer research , biology , gene mutation , gene , pathology , mutation , medicine , genetics , signal transduction , pi3k/akt/mtor pathway
Irradiation to the head is associated with a significantly increased incidence of meningiomas. Radiation‐induced meningiomas morphologically resemble their sporadically arising counterparts; however, they frequently exhibit a more malignant phenotype. Several genes have been shown to carry mutations in meningiomas, with the NF2 gene being most frequently affected. To examine whether the NF2 gene also plays a role in the development of radiation‐induced meningiomas, we compiled a series of meningiomas from 25 patients with a history of previous cranial radiation. This series was compared with 21 atypical WHO grade II meningiomas and 15 anaplastic WHO grade III meningiomas, all from patients without a history of prior irradiation. NF2 mutations occurred significantly more often in sporadic atypical and anaplastic than in radiation‐induced meningiomas ( p < 0.02). In addition, all meningiomas were examined for mutations in the PTEN, TP53, HRAS, KRAS and NRAS genes. Two mutations in the TP53 gene in a sporadic and a radiation‐induced tumor were detected. PTEN mutations were observed in 1 anaplastic and 1 radiation‐induced meningioma. No structural alterations were seen in the RAS genes. Our data suggest that, while there is a certain overlap in the mutational spectrum, NF2 mutations may not play such a prominent role in the pathogenesis of radiation‐induced compared to sporadic meningiomas. © 2001 Wiley‐Liss, Inc.