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International trends and patterns of primary liver cancer
Author(s) -
McGlynn Katherine A.,
Tsao Lilian,
Hsing Ann W.,
Devesa Susan S.,
Fraumeni Joseph F.
Publication year - 2001
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.1456
Subject(s) - developing country , incidence (geometry) , medicine , developed country , cancer , population , primary cancer , seroprevalence , environmental health , demography , immunology , economic growth , antibody , serology , physics , sociology , optics , economics
Primary liver cancer (PLC) is common in many areas of the developing world, but uncommon in most of the developed world. Some evidence suggests, however, that the global pattern of PLC may be changing. To clarify this issue, we examined incidence rates for PLC over the 15‐year time period, 1978–92, in selected cancer registries around the world. With some exceptions, developed countries have experienced PLC increases in incidence whereas developing countries have experienced declines. Although the reasons for the trends are not entirely clear, the increased seroprevalence of HCV in the developed world and the elimination of HBV‐cofactors in the developing world are likely to have contributed to the patterns. Further progress against PLC may be seen in the developing world once the HBV‐vaccinated segment of the population reaches adulthood. Published 2001 Wiley‐Liss, Inc.