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TENB2, a proteoglycan identified in prostate cancer that is associated with disease progression and androgen independence
Author(s) -
GlynneJones Eveline,
Harper Maureen E.,
Seery Liam T.,
James Rhianedd,
Anglin Ian,
Morgan Helen E.,
Taylor Kathryn M.,
Gee Julia M.,
Nicholson Robert I.
Publication year - 2001
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.1450
Subject(s) - prostate cancer , prostate , proteoglycan , cancer research , cancer , biology , growth factor , chondroitin sulfate proteoglycan , androgen receptor , medicine , endocrinology , receptor , microbiology and biotechnology , extracellular matrix
TENB2 encodes a putative transmembrane proteoglycan, related to the EGF/heregulin family of growth factors and follistatin, which has been identified through the application of a differential display technique to a xenograft model of prostate cancer. Northern analysis and competitive PCR were used to demonstrate significantly increased TENB2 expression ( p = 0.0003) on the acquisition of androgen independence in the model system. TENB2 is also overexpressed in clinical prostate carcinoma vs. its benign counterpart ( p < 0.0001), with particular prominence in high‐grade tumours, and shows a high degree of tissue specificity, being detected on a multitissue Northern array exclusively in brain and prostate material. Studies of recombinant protein expression demonstrate that TENB2 is a chondroitin sulphate proteoglycan. The presence of an EGF and 2 follistatin domains suggests a role in the regulation of growth factor signalling either as a ligand precursor, a membrane‐bound receptor or as a binding protein for growth factors. These data are indicative of a significant role for TENB2 in the progression of poorly differentiated tumour types, with implications for prostate cancer detection, prognosis and therapy. © 2001 Wiley‐Liss, Inc.