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Involvement of parathyroid hormone–related protein in experimental cachexia induced by a human lung cancer–derived cell line established from a bone metastasis specimen
Author(s) -
Iguchi Haruo,
Onuma Etsuro,
Sato Koh,
Sato Kanji,
Ogata Etsuro
Publication year - 2001
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.1425
Subject(s) - parathyroid hormone related protein , cachexia , medicine , endocrinology , lung cancer , adipose tissue , cancer , hormone , parathyroid hormone , calcium
Cachexia often causes deterioration in the quality of life in cancer patients; however, its mechanism remains poorly understood. Cachexia has often been observed in experimental animals with bone metastases, and parathyroid hormone–related protein (PTHrP) plays an important role in the formation of such metastases. We therefore investigated the possible involvement of PTHrP in an experimental cachexia model using human lung‐cancer cells (HARA‐B). HARA‐B cells produce a high amount of PTHrP but no TNF‐α, IL‐6 or leukemia inhibitory factor. The s.c. inoculation of HARA‐B cells into nude mice caused reductions in body weight, adipose tissue weight, muscle weight and serum glucose levels. Serum levels of calcium and PTHrP increased. Neutralization of PTHrP with antibody caused rapid weight gain along with a rapid decrease in serum calcium levels. Our findings suggest that PTHrP plays an important role in the development of cancer cachexia. PTHrP therefore is a possible target molecule for the treatment of cancer cachexia. © 2001 Wiley‐Liss, Inc.