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Lifetime residential and workplace exposure to environmental tobacco smoke and lung cancer in never‐smoking women, Canada 1994–97
Author(s) -
Johnson Kenneth C.,
Hu Jinfu,
Mao Yang
Publication year - 2001
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.1416
Subject(s) - medicine , tobacco smoke , passive smoking , lung cancer , confidence interval , odds ratio , spouse , environmental health , demography , population , smoke , tobacco control , public health , pathology , physics , sociology , anthropology , meteorology
Although the risk of lung cancer among never‐smokers living with a spouse who smokes has been extensively studied, the impact of lifetime residential and workplace environmental tobacco smoke has received less attention. As part of a large population‐based case‐control study of lung cancer, we collected lifetime residential and occupational passive smoking information from 71 women with lung cancer and 761 healthy control subjects, all of whom reported being lifetime nonsmokers. The adjusted odds ratio (OR) for lung cancer associated with residential passive exposure only was 1.21 (95% confidence interval [CI] 0.5–2.8). Although more years of and more intense residential passive smoke exposure tended to be associated with higher risk estimates, no clear dose‐response relationship was evident. The OR for women with passive exposure as a child and as an adult was 1.63 (95% CI 0.8–3.5) and for those only exposed as an adult 1.20 (95%CI 0.5–3.0). Exposure to environmental tobacco smoke only in the workplace was associated with an adjusted OR of 1.27 (95% CI 0.4–4.0). Risks associated with increasing occupational exposure year tertiles were 1.24, 1.71 and 1.71. Total smoker‐years of residential and occupational exposure combined resulted in a statistically significant trend (linear test for trend p = 0.05) with ORs for tertiles of exposure of 0.83, 1.54 and 1.82. Our results are consistent with the literature suggesting that long‐term, regular exposure to either residential or occupational environmental tobacco smoke is associated with increased lung cancer risk in never‐smoking women. © 2001 Wiley‐Liss, Inc.