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Mitochondrial DNA alteration in esophageal cancer
Author(s) -
Hibi Kenji,
Nakayama Hiroshi,
Yamazaki Taiji,
Takase Tsunenobu,
Taguchi Masumi,
Kasai Yasushi,
Ito Katsuki,
Akiyama Seiji,
Nakao Akimasa
Publication year - 2001
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.1204
Subject(s) - mitochondrial dna , esophageal cancer , biology , d loop , somatic cell , mutation , dna , genetics , cancer , microbiology and biotechnology , mitochondrion , mtdna control region , cancer research , gene , genotype , haplotype
It has been reported that various cancers frequently have mutations in the D‐loop region of mitochondrial DNA (mtDNA). We examined the genetic alterations in this region of esophageal cancer using direct sequencing. Of 68 sequence variants, 15 have not been reported to date. Tumor mtDNA with these variants were compared with mtDNA from corresponding normal esophageal mucosa. Two of 37 primary esophageal cancers (5%) contained somatic mutations in the D‐loop region of mtDNA. Although the mutation rate of mitochondrial tumor DNA within the D‐loop was not high, this result suggested that mtDNA mutations play a role in the development of esophageal cancer. © 2001 Wiley‐Liss, Inc.