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Clinical value of p53, c‐erbB‐2, CEA and CA125 regarding relapse, metastasis and death in resectable non‐small cell lung cancer
Author(s) -
Pollán Marina,
Varela Gonzalo,
Torres Antonio,
de la Torre Mercedes,
Ludeña M Dolores,
Ortega M Dolores,
Pac Joaquín,
Freixenet Jorge,
Gómez Guillermo,
Sebastián Fernando,
Díez Manuel,
Arrabal Ricardo,
Canalís Emili,
GarcíaTirado Javier,
Arnedillo Aurelio,
Rivas Juan José,
Minguella Joan,
Gómez Ana,
García Mauricio,
Aragonés Nuria,
PérezGómez Beatriz,
LópezAbente Gonzalo,
GonzálezSarmiento Rogelio,
Rojas Jose María
Publication year - 2003
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.11472
Subject(s) - medicine , oncology , lung cancer , metastasis , context (archaeology) , proportional hazards model , cancer , population , immunostaining , pathological , lung , immunohistochemistry , environmental health , biology , paleontology
The prognostic value of p53 and c‐erbB‐2 immunostaining and preoperative serum levels of CEA and CA125 was investigated in a prospective multicentric study including 465 consecutive non‐small cell lung cancer (NSCLC) patients with resectable tumors. Four end‐points were used: lung cancer death, first relapse (either locoregional or metastasis), loco‐regional recurrence and metastasis development. Standard statistical survival methods (Kaplan‐Meier and Cox regression) were used. The specificity of the prognostic effect across different types of tumors was also explored, as had been planned in advance. Our results showed, once again, that pathological T and N classifications continue to be the strongest predictors regarding either relapse or mortality. Three of the studied markers seemed to add further useful information, however, but in a more specific context. For example, increased CEA concentration defined a higher risk population among adenocarcinomas but not among people with squamous tumors; and p53 overexpression implied a worse prognosis mainly in patients with well differentiated tumors. The analysis of type of relapse proved to be very informative. Thus, CA125 level was associated with a worse prognosis mainly related with metastasis development. Another interesting result was the influence of smoking, which showed a clear dose‐response relationship with the probability of metastasis. For future studies, we recommend the inclusion of different endpoints, namely considering the relationship of markers with the type of relapse involved in lung‐cancer recurrence. They can add useful information regarding the complex nature of prognosis. © 2003 Wiley‐Liss, Inc.