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Loss of FHIT protein expression is a marker of adverse evolution in good prognosis localized breast cancer
Author(s) -
Ginestier Christophe,
Bardou ValérieJeanne,
Popovici Cornel,
CharafeJauffret Emmanuelle,
Bertucci François,
Geneix Jeannine,
Adélaïde José,
Chaffanet Max,
Hassoun Jacques,
Viens Patrice,
Jacquemier Jocelyne,
Birnbaum Daniel
Publication year - 2003
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.11462
Subject(s) - fhit , breast cancer , tissue microarray , medicine , oncology , immunohistochemistry , cancer , chemotherapy , pathology , tumor suppressor gene , carcinogenesis
The FHIT tumor suppressor gene, which encompasses the fragile site FRA3B at 3p14.2, is altered frequently in many types of human cancers. To determine its importance as a prognostic marker in breast cancer, the expression of the FHIT protein was studied in a series of 452 breast carcinomas by using immunohistochemistry on sections of tissue microarrays. Three distinct levels of FHIT expression were observed: in 154 cases (34.1%) expression was unchanged as compared to normal level; in 78 (17.2%) no expression was found; in the remaining 220 cases (48.7%), expression was intermediate. Overall, two‐thirds of the cases had abnormal levels of the protein. Absence of FHIT was significantly associated with a higher grade ( p < 0.01) and absence of hormone receptors ( p < 0.001). The patients were separated into Group I (153 node‐negative good prognosis patients who did not receive adjuvant chemotherapy) and Group II (226 high‐risk patients treated by adjuvant chemotherapy) according to the St.‐Gallen conference consensus. The median follow‐up was 48 months. Among Group I but not Group II patients, a multivariate analysis showed that FHIT expression was significantly associated with disease‐free survival. The relative risk of recurrence for FHIT‐negative Group I patients was 2.37 (1.21–4.64; p = 0.03). Thus, among the patients who present with tumors of apparent good prognosis, FHIT is an independent prognostic factor that distinguishes a subgroup of patients who could benefit from adjuvant treatment. © 2003 Wiley‐Liss, Inc.