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Breast cancer in young women (≤35 years): Genomic aberrations detected by comparative genomic hybridization
Author(s) -
WeberMangal Susanne,
Sinn HansPeter,
Popp Susanne,
Klaes Rüdiger,
Emig Robert,
Bentz Martin,
Mansmann Ulrich,
Bastert Gunther,
Bartram Claus R.,
Jauch Anna
Publication year - 2003
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.11460
Subject(s) - comparative genomic hybridization , breast cancer , grading (engineering) , biology , chromosome , metastasis , pathological , oncology , lymph node , medicine , cancer , pathology , cancer research , genetics , gene , ecology
Abstract Sporadic breast cancer in young women is different from the one in older patients regarding pathological features and aggressiveness of the tumors, but the spectrum of genetic alterations are largely unknown. We used comparative genomic hybridization (CGH) to analyze DNA copy number changes in 88 tumor samples from women ≤35 years of age. Findings were compared to histopathological data including tumor type, grading, lymph nodes and metastasis. Genomic gains clustered to chromosome arms 1q (64.8%), 8q (61.4%), 17q (50.0%), 20q (33.0%), 3q (20.5%), 1p (17.0%), 5p (17.0%) and 15q (17%). Losses were commonly located on 8p (19.3 %), 11q (11.4%), 16q (11.4%), 17p (11.4%) and 18q (10.2%). A comparison with published CGH data from breast carcinomas of similar type and grade showed the following differences: (1) gains were much more frequent than losses, and (2) losses on 8p22–p23 were more prevalent in patients with positive lymph node metastasis ( p = 0.02), and Grade III tumors were associated with gains on the long arm of chromosome 8 ( p = 0.01). Therefore, alterations in these genomic regions may be responsible for the reduced survival of patients with early onset breast cancer. © 2003 Wiley‐Liss, Inc.