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Human papillomavirus type 16 E6 variants and HLA class II alleles among Japanese women with cervical cancer
Author(s) -
Matsumoto Koji,
Yasugi Toshiharu,
Nakagawa Shunsuke,
Okubo Mitsuo,
Hirata Ranko,
Maeda Hiroo,
Yoshikawa Hiroyuki,
Taketani Yuji
Publication year - 2003
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.11332
Subject(s) - human leukocyte antigen , cervical cancer , allele , genetics , biology , human papillomavirus , carcinogenesis , population , polymorphism (computer science) , immunology , antigen , cancer , medicine , gene , environmental health
Abstract The enhanced oncogenicity of particular human papillomavirus type 16 (HPV16) E6 variants is population‐dependent, implying the involvement of additional genetic cofactors. This study was designed to investigate the association between E6 variants and human leukocyte antigen (HLA) polymorphism within a Japanese population. Fifty‐seven women with HPV16‐positive cervical cancer were analyzed for E6 sequence variation and its relationship to HLA class II alleles. Compared with local controls (n = 138) and published controls (n = 916), DRB1*1501 and DQB1*0602 frequencies were significantly increased among patients with HPV16 E6 prototype (n = 11). Additionally, DRB1*1502 was positively associated with a particular E6 variant designated D25E (n = 25), although we could not find a significant association between HLA class II alleles and L83V variants (n = 16). Our observations suggest that a specific match between E6 variant proteins and HLA types may contribute to HPV16‐related cervical carcinogenesis. © 2003 Wiley‐Liss, Inc.