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Oral contraceptive use and risk of breast cancer by histologic type
Author(s) -
Newcomer Laura M.,
Newcomb Polly A.,
TrenthamDietz Amy,
Longnecker Matthew P.,
Greenberg E. Robert
Publication year - 2003
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.11307
Subject(s) - medicine , odds ratio , breast cancer , gynecology , population , cancer , lobular carcinoma , confidence interval , risk factor , ductal carcinoma , case control study , carcinoma , obstetrics , oncology , environmental health
We examined the association between oral contraceptive use and risk of specific breast cancer histopathologies in a large, multi‐center, population‐based, case‐control study. Women younger than age 75 with a new diagnosis of invasive breast cancer were identified from 4 statewide tumor registries. We compared women with lobular ( n = 493) and ductal carcinoma ( n = 5,510) to randomly selected controls ( n = 9,311). Odds ratios (OR) and 95% confidence intervals (CI) for each histologic type were estimated using polytomous logistic regression, adjusted for other breast cancer risk factors. Current oral contraceptive use was associated with increased risk of lobular carcinoma (OR = 2.6, 95%CI = 1.0–7.1) and there was a significant trend ( p = 0.017) of increased risk with more recent use. Oral contraceptive use was not clearly associated with ductal carcinoma (OR = 1.2, 95%CI = 0.8–1.9). These results suggest that the association between oral contraceptive use and risk of breast cancer may vary by histologic type. © 2003 Wiley‐Liss, Inc.