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Frequent allelic changes at chromosome 7q34 but lack of mutation of the BRAF in papillary renal cell tumors
Author(s) -
Nagy Anett,
Balint Ildiko,
Kovacs Gyula
Publication year - 2003
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.11305
Subject(s) - chromophobe cell , locus (genetics) , exon , allele , biology , cancer research , pathology , papillary renal cell carcinomas , mutation , clear cell , genetics , renal cell carcinoma , medicine , gene , kidney
We have analyzed the BRAF locus on chromosome 7q34 with microsatellites for allelic changes and exons 11 and 15 of the BRAF with sequencing for mutations in 50 kidney cancers including 20 papillary, 15 conventional and 15 chromophobe renal cell carcinomas (RCC). Allelic changes at the BRAF locus were seen in 16 of the 20 papillary, 3 of the 15 conventional RCCs and 2 of the 15 chromophobe RCCs. Sequencing failed to disclose mutations in exons 11 and 15 of the BRAF gene in any of the tumors. Our data indicate that BRAF mutation does not play a role in the development of renal cell tumors. © 2003 Wiley‐Liss, Inc.