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Ectopic chromosome around centrosome in metaphase cells as a marker of high‐risk human papillomavirus–associated cervical intraepithelial neoplasias
Author(s) -
Furuta Reiko,
Hirai Yasuo,
Katase Katsuyoshi,
Tate Shinichi,
Kawaguchi Tokuichi,
Akiyama Futoshi,
Kato Yo,
Kumada Kazuki,
Iwasaka Tsuyoshi,
Yaegashi Nobuo,
Kanazawa Koji,
Yoshikawa Hiroyuki,
Kitagawa Tomoyuki
Publication year - 2003
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.11216
Subject(s) - centrosome , biology , metaphase , carcinogenesis , chromosome , pathology , cancer research , cell , medicine , cancer , genetics , cell cycle , gene
Abstract This report describes the appearance of ectopic chromosome around centrosome (ECAC) in metaphase cell nuclei of high‐risk HPV‐associated cervical neoplasms. ECAC are clearly visible on HE‐stained sections as a tiny (approx. 0.7 μ), round, dark structure or an aggregate of filamentous chromosome, often symmetrical at bilateral centrosomes. They appear in CINs from an early stage (CIN I), with the highest incidence in HPV16‐associated CIN II–III (75%), and are less common in HPV‐related invasive carcinomas (21%) and in lesions associated with high‐risk HPV types other than 16. Rates for ECAC‐positive nuclei in metaphase preparations (ECAC rate) for each lesion ranged 3.6–30%, the average being 14.5%. ECAC appeared very rarely in CINs associated with intermediate‐risk HPVs and was never encountered in HPV6/11‐induced condylomas or HPV‐unrelated neoplasms in other organs. ECAC may be morphologic evidence of HPV‐induced chromosomal instability working as a background mechanism in cervical carcinogenesis and also a useful marker for the histopathologic differentiation of high‐risk CINs. © 2003 Wiley‐Liss, Inc.