Premium
BCL‐2/J H translocation in peripheral blood lymphocytes of unexposed individuals: Lack of seasonal variations in frequency and molecular features
Author(s) -
Roulland Sandrine,
Lebailly Pierre,
Roussel Gilbert,
Briand Mélanie,
Cappellen David,
Pottier Didier,
Hardouin Agnès,
Troussard Xavier,
Bastard Christian,
HenryAmar Michel,
Gauduchon Pascal
Publication year - 2003
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.10975
Subject(s) - chromosomal translocation , genotoxicity , confounding , peripheral blood , population , biology , medicine , microbiology and biotechnology , physiology , genetics , immunology , toxicity , gene , environmental health
BCL‐2/J H rearrangement has been proposed as a biomarker for evaluating the genotoxicity of occupational and environmental exposures. Available data on time‐related modification of this rearrangement in peripheral blood lymphocytes in unexposed healthy individuals is scarce. We investigated the characteristics of BCL‐2/J H rearrangements in 33 adults unexposed to genotoxins at 2 seasonal time points: winter and spring. BCL‐2/J H rearrangement was detected in 79% of individuals (detection limit = 8.48 × 10 −8 ). Its frequency ranged from <1 to 40 translocations per million lymphocytes with a significant ( p = 0.04) positive correlation with age. No significant modifications of BCL‐2/J H rearrangement frequency or in the number of clones harboring this rearrangement were observed according the 2 time points. No obvious influence of season‐related environmental factors on frequency or molecular features of BCL‐2/J H rearrangements was found in this population suggesting that this would not be a confounding factor. © 2003 Wiley‐Liss, Inc.