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The product of the candidate prostate cancer susceptibility gene ELAC2 interacts with the γ‐tubulin complex
Author(s) -
Korver Wouter,
Guevara Claudia,
Chen Yang,
Neuteboom Saskia,
Bookstein Rob,
Tavtigian Sean,
Lees Emma
Publication year - 2003
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.10945
Subject(s) - biology , mitosis , cancer research , carcinogenesis , prostate cancer , chromoplexy , genetics , gene , cancer , pca3
ELAC2 is a novel candidate cancer susceptibility gene located on chromosome 17p: Carriers of mutations in ELAC2 display a higher risk of developing prostate cancer. Overexpression of ELAC2 in tumor cells causes a delay in G2‐M progression characterized by accumulation of cyclin B levels. Consistent with a function in mitosis, further biochemical analysis revealed that ELAC2 physically interacts with the γ‐tubulin complex. This is the first biologic insight into the function of this new putative cancer susceptibility gene, providing clues of how perturbation of ELAC2 might promote tumorigenesis through irregular cell division. © 2003 Wiley‐Liss, Inc.