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Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF‐7 human breast cancer cell
Author(s) -
Hu Hongbo,
Ahn NamShik,
Yang Xinlin,
Lee YongSoon,
Kang KyungSun
Publication year - 2002
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.10707
Subject(s) - mcf 7 , apoptosis , ganoderma , ganoderma lucidum , cancer research , cell cycle , cell growth , cell , programmed cell death , cell cycle checkpoint , biology , cyclin d1 , cancer cell , immune system , cancer , pharmacology , chemistry , medicine , traditional medicine , immunology , biochemistry , human breast
Although the pharmacology and clinical application of water extracts of Ganoderma lucidum have been extensively documented, little is known regarding its alcohol extract. In the present study, the anti‐tumor effect of an alcohol extract of Ganoderma lucidum was investigated using MCF‐7 cells. We found that the alcohol extract of Ganoderma lucidum inhibited cell proliferation in a dose‐ and time‐dependent manner, which might be mediated through up‐regulation of p21/Waf1 and down‐regulation of cyclin D1. Furthermore, this compound can directly induce apoptosis in MCF‐7 cells, which might be mediated through up‐regulation of a pro‐apoptotic Bax protein and not by the immune system. Our findings suggest that there are multiple mechanisms underlying the anti‐tumor effects of Ganoderma lucidum . © 2002 Wiley‐Liss, Inc.