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Oesophageal adenocarcinoma: A paradigm of mechanical carcinogenesis?
Author(s) -
La Vecchia Carlo,
Negri Eva,
Lagiou Pagona,
Trichopoulos Dimitrios
Publication year - 2002
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.10697
Subject(s) - reflux , adenocarcinoma , obesity , incidence (geometry) , medicine , abdominal obesity , cancer , gastroenterology , disease , metabolic syndrome , physics , optics
Incidence of adenocarcinoma of the oesophagus and gastric cardia is increasing in most developed countries and strongly associated with obesity and male gender. An underlying increase in the prevalence of gastro‐oesophageal reflux has generally been postulated. We suggest that the increase in frequency of reflux and the 2 associated forms of cancer can be explained by growing abdominal pressure brought about by increasing central obesity, most common among men, and sedentary lifestyle, including car use. Abdominal pressure is further accentuated mainly in men by the shift in Western male dressing towards the general use of belts. © 2002 Wiley‐Liss, Inc.