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Single‐nucleotide polymorphism in the E‐cadherin gene promoter modifies the risk of prostate cancer
Author(s) -
Verhage Bas A.J.,
van Houwelingen Kjeld,
Ruijter T. Emiel G.,
Kiemeney Lambertus A.,
Schalken Jack A.
Publication year - 2002
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.10541
Subject(s) - genotype , single nucleotide polymorphism , allele , prostate cancer , snp , biology , gene , promoter , genetics , microbiology and biotechnology , medicine , cadherin , cell , cancer , gene expression
E‐cadherin plays a major role in intercellular adhesion, cell polarity and tissue architecture. We determined the relative risk of PCa associated with a previously reported C/A SNP at −160 bp relative to the transcription‐start site of the E‐cadherin gene promoter. Eighty‐two PCa patients and 188 controls were genotyped. Genotype and allele frequencies differed significantly among cases and controls. A‐allele carriers had a higher relative risk of PCa (OR = 3.6, 95% CI 2.0–6.4) compared to C‐only carriers. AC and AA genotypes had an increased risk of PCa (OR = 3.8, 95% CI 2.1–6.8 and OR = 1.7, 95% CI 0.4–6.6, respectively) compared to CC genotypes. © 2002 Wiley‐Liss, Inc.