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Prevalence of human papillomavirus in cervical cancer: A multicenter study in China
Author(s) -
Lo Keith W.K.,
Wong Y.F.,
Chan May K.M.,
Li James C.B.,
Poon J.S.,
Wang Vivian W.,
Zhu S.N.,
Zhang T.M.,
He Z.G.,
Wu Q.L.,
Li G.D.,
Tam John S.L.,
Kahn T.,
Lam P.,
Cheung T.H.,
Chung Tony K.H.
Publication year - 2002
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.10506
Subject(s) - cervical cancer , human papillomavirus , medicine , hpv infection , oncology , basal cell , adenocarcinoma , epidemiology , gynecology , cervical carcinoma , cancer , virology
A large‐scale epidemiologic survey on the prevalence of different types of human papillomavirus (HPV) in cervical cancer in China is indicated because of the implications for the development of diagnostic probes and vaccines against cervical cancer. A total of 809 cervical cancer specimens were collected from 5 regions in China including Shanghai, Guangzhou, Sichuan, Beijing and Hong Kong. HPV DNA was detected in 83.7% of the specimens. HPV‐16 was present in 79.6%, HPV‐18 in 7.5%, HPV‐52 in 2.6% and HPV‐58 in 3.8% of all HPV‐positive specimens. The prevalences of HPV‐16 and HPV‐18 in Hong Kong were 61.7 and 14.8%, respectively, representing a lower HPV‐16 and a higher HPV‐18 proportion compared with the other regions. HPV‐16 remained the most common HPV infection in both squamous cell carcinoma (SCC) and adenocarcinoma (AC). The proportion of HPV‐18 infection was significantly higher in AC than in SCC. © 2002 Wiley‐Liss, Inc.