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Mucin phenotype and microsatellite instability in early multiple gastric cancers
Author(s) -
Takahashi Hiroaki,
Endo Takao,
Yamashita Kentaroh,
Arimura Yoshiaki,
Yamamoto Hiroyuki,
Sasaki Shigeru,
Itoh Fumio,
Hirata Koichi,
Imamura Akimichi,
Kondo Masafumi,
Sato Toshihiro,
Imai Kohzoh
Publication year - 2002
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.10501
Subject(s) - intestinal metaplasia , mucin , microsatellite instability , pathology , phenotype , cancer , immunohistochemistry , adenocarcinoma , biology , medicine , metaplasia , gastroenterology , microsatellite , gene , genetics , allele
Clinicopathologically, multiple gastric cancers (MGCs) are reported to involve predominantly intestinal‐type adenocarcinoma and frequently to be associated with severe intestinal metaplasia. However, there are few reports concerning the characteristic biomarkers of early MGCs. The aim of our study was to identify the cellular lineage defined by mucin phenotypes and the relationships among mucin phenotypes, background mucosa and microsatellite instability (MSI) of early MGCs. We examined mucin phenotypes of 63 surgically resected carcinomas from 25 patients with early MGCs and 39 early solitary gastric cancers (SGCs) by immunohistochemical analysis using a panel of monoclonal antibodies. MSI and the degree of intestinal metaplasia (IM) on the background mucosa were also examined. In early MGCs, the incidence of cancer exhibiting the gastric phenotype (G‐type) was 59% (37 of 63 cancers), which was higher than that in early SGCs (23%, 9 of 39 cancers). There was a significant difference between the distributions of mucin phenotypes in early MGCs and early SGCs ( p = 0.001). Whereas half of the G‐type cancers in early MGCs were related to severe IM, none of the G‐type cancers in early SGCs were related to severe IM. In the early MGCs, MSI was observed in 21 of 63 cancers (33.3%). In contrast, MSI was observed in only 3 of the 39 (7.7%) early SGCs, indicating a significant difference between these 2 groups ( p < 0.01). Our results suggest that the characteristic features of early MGCs are the gastric mucin dominant phenotype and high frequency of MSI. © 2002 Wiley‐Liss, Inc.