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Post‐menopausal hormonal therapy and gallbladder cancer risk
Author(s) -
Gallus Silvano,
Negri Eva,
Chatenoud Liliane,
Bosetti Cristina,
Franceschi Silvia,
La Vecchia Carlo
Publication year - 2002
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.10411
Subject(s) - medicine , odds ratio , gallbladder cancer , epidemiology , gallbladder disease , hormone replacement therapy (female to male) , confidence interval , cancer , gallbladder , hormonal therapy , hormone , hormone therapy , gynecology , case control study , oncology , prostate cancer , breast cancer , testosterone (patch)
The relation between post‐menopausal hormone replacement therapy (HRT) and gallbladder cancer was analyzed in women above age 45 years, using data of a case‐control study conducted in Italy between 1985 and 1997, on 31 incident, histologically confirmed cases and 3,702 controls in hospital for acute, non‐neoplastic conditions. The multivariate odds ratio (OR) was 3.2 (95% confidence interval: 1.1–9.3) for those who had ever used HRT and the OR tended to rise with longer duration. Although based on small numbers, due to the rarity of the disease, these findings provide the first direct epidemiological evidence of an association between HRT and gallbladder cancer. © 2002 Wiley‐Liss, Inc.