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HOGG1 Ser 326 Cys polymorphism and modification by environmental factors of stomach cancer risk in Chinese
Author(s) -
Takezaki Toshiro,
Gao Changming,
Wu Jianzhong,
Li Zhongyou,
Wang Jiandong,
Ding Jianhua,
Liu Yanting,
Hu Xu,
Xu Tianliang,
Tajima Kazuo,
Sugimura Haruhiko
Publication year - 2002
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.10400
Subject(s) - stomach cancer , stomach , odds ratio , allele , genetics , cancer , biology , gastroenterology , case control study , gene , medicine
Oxidative stress is involved in many types of DNA damage, e.g., resulting in 8‐hydroxyguanine adducts. Since a human counterpart exists for the yeast gene OGG1 ( hOGG1 ) encoding an enzyme that repairs 8‐hydroxyguanine, its polymorphism, Ser 326 Cys, might have potential as a genetic marker for cancer susceptibility. To investigate its association with stomach cancer risk and possible interactions with environmental factors, we conducted a case‐control study of 101 stomach cancer cases and 198 controls using PCR‐single‐strand conformation polymorphism and a questionnaire approach. The proportional distribution of the Cys/Cys alleles did not differ between stomach cancer cases and controls, but subgroup analyses revealed that a frequent drinking habit elevated the odds ratio (OR) for stomach cancer in Cys/Cys compared to Ser/Ser and Ser/Cys carriers. The ORs with frequent consumption of pickled vegetables and meat tended to be higher in Cys/Cys than in Ser/Ser and Ser/Cys carriers, these interactions being on the borderline of statistical significance. Our findings suggest that the hOGG1 Ser 326 Cys polymorphism may alter the impact of some environmental factors on stomach cancer development. For confirmation, an additional study with a larger number of subjects is now required. © 2002 Wiley‐Liss, Inc.