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Phage display particles expressing tumor‐specific antigens induce preventive and therapeutic anti‐tumor immunity in murine p815 model
Author(s) -
Wu Yuzhang,
Wan Ying,
Bian Jiang,
Zhao Jianping,
Jia ZhengCai,
Zhou Liyun,
Zhou Wei,
Tan Yang
Publication year - 2002
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.10260
Subject(s) - mastocytoma , immune system , antigen , immunization , ctl* , immunotherapy , epitope , phage display , immunology , cancer research , medicine , biology , antibody , tumor cells , cd8
The efficacy of phage display particles expressing tumor antigen P1A35‐43 in inducing protective and therapeutic anti‐tumor immune responses were studied. A protective immune response against a lethal progressive P815 mastocytoma tumor cell challenge was established after subcutaneous injection of phage display particles. Furthermore, the vaccine suppressed growth of pre‐existing tumors. Immunization with the hybrid phage particles elicited P1A 35–43 specific CTL responses and a Th1‐dominated immune response with phage particle‐specific secretion of IFN‐γ but not IL‐4. Our results indicate that phage display particles might be a useful vaccine form for tumor‐associated antigen epitopes in tumor immunotherapy. © 2002 Wiley‐Liss, Inc.