CD70/CD27 ligand, a member of the TNF family, is expressed in human brain tumors
Author(s) -
HeldFeindt Janka,
Mentlein Rolf
Publication year - 2002
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.10207
Subject(s) - glioma , biology , cancer research , meningioma , tumor necrosis factor alpha , ligand (biochemistry) , receptor , cell culture , cell , immunology , pathology , medicine , genetics
Abstract CD70 (CD27 ligand) has been implicated in proapoptotic signals mediated by its receptor CD27 in lymphocytes as well as in proliferative effects induced by reverse signaling in CD70‐positive hematopoetic tumor cells. We were able to show that CD70 is expressed at the mRNA and protein level in human meningioma cells, glioma cells from solid human gliomas as well as glioma cell lines and 1 ependynoma. The intensity of CD70 expression varies considerably between different samples from 1 tumor type. In the U343 glioma cell line, CD70 was preferentially localized in the cell processes. Thus, our studies identify CD70 as a new marker molecule in brain tumors that are of nonhematopoetic origin. © 2002 Wiley‐Liss, Inc.