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Acute hyperglycemia impairs IL‐6 expression in humans
Author(s) -
Spindler Matthew P.,
Ho Alvin M.,
Tridgell David,
McCullochOlson Marli,
Gersuk Vivian,
Ni Chester,
Greenbaum Carla,
Sanda Srinath
Publication year - 2016
Publication title -
immunity, inflammation and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 18
ISSN - 2050-4527
DOI - 10.1002/iid3.97
Subject(s) - immune system , cd14 , innate immune system , peripheral blood mononuclear cell , biology , endocrinology , medicine , immunology , immunity , in vitro , biochemistry
Normal glucose metabolism is critical to immune function but the effects of short‐term hyperglycemia on immunity are not well described. To study this phenomenon, we induced hyperglycemia in healthy subjects for 2 h with intravenous dextrose and octreotide. An RNA‐seq analysis of whole blood RNA demonstrated alterations in multiple immune pathways and transcripts during acute hyperglycemia including decreased transcription of IL‐6, an important component of both innate and adaptive immune responses. Additional in vitro studies of human peripheral blood mononuclear cells (PBMCs) exposed to high glucose confirmed decreased IL‐6 expression, most prominently in CD14 + CD16 + intermediate monocytes. Hyperglycemia also reduced IL‐17A expression suggesting further impairment of immune responses during acute hyperglycemia. These findings demonstrate multiple defective immune responses in acute hyperglycemia and suggest a novel role for intermediate monocytes as metabolically sensitive innate immune cells.

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