Open AccessCD4 + T effector memory cell responses in Chlamydia pneumoniae ‐stimulated peripheral blood mononuclear cells in nonasthmatic subjects
Author(s) -
SmithNorowitz Tamar A.,
Shidid Sarah,
Norowitz Yitzchok M.,
Kohlhoff Stephan
Publication year - 2022
Publication title -
immunity, inflammation and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 18
ISSN - 2050-4527
DOI - 10.1002/iid3.726
Subject(s) - immunology , chlamydia , peripheral blood mononuclear cell , effector , asthma , chlamydophila pneumoniae , pathophysiology , biology , respiratory system , t cell , medicine , in vitro , immune system , chlamydiaceae , pathology , genetics
Chlamydia pneumoniae ( C. pneumoniae ) is a gram‐negative intracellular bacterium that causes respiratory infection in humans, including subjects with or without asthma. C. pneumoniae activates cells (e.g., monocytes/macrophages) in vitro, and produces cytokines that may contribute to inflammatory responses observed in asthma. Immunological differences exist between subjects with or without asthma, with regard to host responses to C. pneumoniae . The heterogeneity and subsequent diverse pathophysiology of asthma can be better understood by analyzing the repertoire of T‐cell subpopulations; the most common distinction between different asthma endotypes includes cytokines produced by CD4 + cells (T helper (Th)2 high vs. Th2 low).