Open AccessComparison between clinical characteristics and laboratory findings among patients with complicated and noncomplicated SARS‐CoV‐2 infection: A single‐center experience from Shebin Al‐Kom, Egypt
Author(s) -
Fadda Walaa A.,
AlBatay Manal A.,
Aboukhalil Reham E. E.,
Khader Heba F.,
Al Rugaie Osamah
Publication year - 2022
Publication title -
immunity, inflammation and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 18
ISSN - 2050-4527
DOI - 10.1002/iid3.671
Subject(s) - medicine , odds ratio , tachypnea , ferritin , gastroenterology , lymphocytopenia , confidence interval , lactate dehydrogenase , creatinine , alanine transaminase , c reactive protein , tachycardia , lymphocyte , biology , biochemistry , inflammation , enzyme
Background Coronavirus disease 2019 (COVID‐19) infection is considered a serious highly infectious disease caused by severe acute respiratory syndrome coronavirus 2, resulting in more than 6.27 million deaths worldwide. Aim of the study The study aimed to compare clinical characteristics and laboratory findings of COVID‐19 patients with complications and without complications and discriminate the important risk factors for the complications and deaths. Subjects and Methods This cross‐sectional study included 75 confirmed COVID‐19 positive patients; out of which 49 were severely‐ill cases. Analysis of all patients' clinical and laboratory information on admission including serum ferritin, thrombotic activity ( d ‐dimer), lactate dehydrogenase (LDH), C‐reactive protein (CRP), creatinine, aspartate aminotransferase, and alanine aminotransferase were done. Results Lymphopenia, tachycardia, tachypnea, elevated CRP, d ‐dimer, serum ferritin, LDH, and decreased SpO 2 were significantly associated with complicated cases ( p < .05 for all). By using multivariate logistic regression analysis models, elevated serum ferritin and tachycardia were significantly correlated with the increased odds of complicated COVID‐19 cases (odds ratio [confidence interval 95%] = 10.42 [2.32–46.89] and 8.01 [1.17–55.99]; respectively) ( p = .002 and .007, respectively). Conclusion Lymphocytopenia, d ‐dimer, LDH, and CRP levels, which were significantly linked to the severity of COVID‐19, were the prognostic biomarkers to predict the disease severity.