Open AccessEarly use of tocilizumab in solid organ transplant recipients with COVID‐19: A retrospective cohort study in Saudi Arabia
Author(s) -
Yamani Amani H.,
Alraddadi Basem M.,
Almaghrabi Reem S.,
Amer Afnan A.,
Mehdawi Fatimah S.,
ALHamzi Mohammed A,
Aldajani Meshari S.,
Alattas Majda S.,
Elsaed Ramadan Aiman M.,
Wali Ghassan Y,
Alshukairi Abeer N.,
Al Mutair Abbas
Publication year - 2022
Publication title -
immunity, inflammation and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 18
ISSN - 2050-4527
DOI - 10.1002/iid3.587
Subject(s) - tocilizumab , medicine , pneumonia , retrospective cohort study , mechanical ventilation , cytokine release syndrome , standard of care , covid-19 , surgery , rheumatoid arthritis , disease , infectious disease (medical specialty)
Background Tocilizumab was studied to reduce cytokine syndrome in patients with severe COVID‐19 pneumonia in solid organ transplant (SOT) recipients with conflicting results. We aim to study the early use of tocilizumab in SOT with COVID‐19 pneumonia on low flow oxygen. Methods This is a retrospective cohort study that was conducted in two transplant centers in Saudi Arabia among 46 SOT with COVID‐19 comparing 21 patients who received tocilizumab to 25 patients who received standard of care. Their clinical characteristics and outcomes were described. Results Compared to patients who received standard of care, patients in the tocilizumab group were older (60.2 ± 12.8 vs. 48.6 ± 12.3, p = .003), had higher ferritin (862.1 ± 919.1 vs. 414 ± 447.3, p = .025) and C‐reactive protein (CRP) (85 ± 83.1 vs. 42.9 ± 57.3, p = .012). More patients in the tocilizumab group required high flow oxygen (38.1% vs. 8.0%, p = .028) compared to patients on standard of care. There were no differences in mortality or mechanical ventilation requirement. Hospital stay was significantly shorter in the tocilizumab group than the standard of care group (9.6 ± 7.4 vs. 20.7 ± 11.7, p < .001). Conclusions Early use of tocilizumab in SOT was associated with a shorter hospital stay. There was no difference in mortality rate and the requirement for mechanical ventilation in both groups.