Open AccessInteractions between NLRP3 inflammasome and glycolysis in macrophages: New insights into chronic inflammation pathogenesis
Author(s) -
Yu Qun,
Guo Maojuan,
Zeng Wenyun,
Zeng Miao,
Zhang Xiaolu,
Zhang Yue,
Zhang Wenlan,
Jiang Xijuan,
Yu Bin
Publication year - 2022
Publication title -
immunity, inflammation and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 18
ISSN - 2050-4527
DOI - 10.1002/iid3.581
Subject(s) - inflammasome , glycolysis , inflammation , microbiology and biotechnology , oxidative phosphorylation , anaerobic glycolysis , chemistry , pathogenesis , biology , biochemistry , enzyme , immunology
NLRP3 inflammasome activation in macrophages fuels sterile inflammation, which has been tied with metabolic reprogramming characterized by high glycolysis and low oxidative phosphorylation. The key enzymes in glycolysis and glycolysis‐related products can regulate and activate NLRP3 inflammasome. In turn, NLRP3 inflammasome is considered to affect glycolysis, as well. However, the exact mechanism remains ambiguous. On the basis of these findings, the focus of this review is mainly on the developments in our understanding of interaction between NLRP3 inflammasome activation and glycolysis in macrophages, and small molecule compounds that influence the activation of NLRP3 inflammasomes by regulating glycolysis in macrophages. The application of this interaction in the treatment of diseases is also discussed. This paper may yield valuable clues for development of novel therapeutic agent for NLRP3 inflammasome‐related diseases.