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Well past time to stop using NOELs and LOELs
Author(s) -
Landis Wayne G,
Chapman Peter M
Publication year - 2011
Publication title -
integrated environmental assessment and management
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 57
eISSN - 1551-3793
pISSN - 1551-3777
DOI - 10.1002/ieam.249
Subject(s) - environmental science , computer science , risk analysis (engineering) , business
The problem with NOELs and LOELs is basic. The fundamental model of environmental toxicology is the exposure–response (or concentration–response or dose– response) curve that describes the relationship between exposure and effect. It is a given that the best possible description of this relationship must be the keystone of the field of toxicology. NOEL and LOELs do not meet the criterion of adequately describing the exposure–response curve. Exposure-Response It’s the curve!