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Orally disintegrating olanzapine and potential differences in treatment‐emergent weight gain
Author(s) -
Karagianis Jamie,
Hoffmann Vicki Poole,
Arranz Belen,
Treuer Tamás,
Maguire Gerald A.,
de Haan Lieuwe,
Chawla Bharat
Publication year - 2008
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.933
Subject(s) - olanzapine , weight gain , medicine , action (physics) , psychology , randomized controlled trial , pharmacology , body weight , psychiatry , schizophrenia (object oriented programming) , physics , quantum mechanics
Several papers and communications have reported possible weight reduction or less weight gain when patients start or switch to orally disintegrating olanzapine, as contrasted with standard oral olanzapine tablets. In this paper, the current literature is reviewed and hypothesized mechanisms of action are discussed. The data are still preliminary and mechanisms of action are not well understood. Randomized controlled trials are needed to further evaluate change in weight during treatment with orally disintegrating olanzapine. Copyright © 2008 John Wiley & Sons, Ltd.