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Prolactin elevation of the antipsychotic risperidone is predominantly related to its 9‐hydroxy metabolite
Author(s) -
Melkersson Kristina I.
Publication year - 2006
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.811
Subject(s) - risperidone , prolactin , metabolite , antipsychotic , morning , medicine , endocrinology , antipsychotic agent , active metabolite , pharmacology , schizophrenia (object oriented programming) , psychiatry , hormone
Objective Treatment with the antipsychotic risperidone is frequently associated with hyperprolactinemia. The aim of this study was to evaluate the role of the main compound risperidone and its active 9‐hydroxy metabolite on elevating prolactin levels. Methods Twenty patients with psychotic disorders, on therapy with risperidone, were studied. All patients had been receiving risperidone for at least 2.5 months, and the median daily dose of risperidone was 3 mg (range 1–10). Morning serum samples for prolactin were analyzed and investigated in relation to the serum concentrations of risperidone and 9‐hydroxyrisperidone. Results Elevated prolactin levels were found in 17 (85%) of the patients. Levels of prolactin were positively correlated to the 9‐hydroxyrisperidone serum concentration (r s = 0.48, p = 0.03) and to the daily dose of risperidone (r s = 0.51, p = 0.03), but did not correlate to the risperidone serum concentration. Conclusion The present results suggest that 9‐hydroxyrisperidone and not risperidone is the main contributor to the increased serum levels of prolactin observed in many risperidone‐treated patients. Copyright © 2006 John Wiley & Sons, Ltd.