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Pharmacokinetic parameters of bromperidol in Korean subjects
Author(s) -
Lee SooYoun,
Kim Yoon Gyoon,
Kim HyungGun,
Kim JongWon
Publication year - 2006
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.776
Subject(s) - pharmacokinetics , adverse effect , medicine , population , plasma concentration , pharmacology , pharmacogenetics , oncology , biology , genetics , genotype , environmental health , gene
We have presented pharmacokinetic parameters of bromperidol (BP) in 14 healthy Korean subjects. Additionally, we have investigated the effects of dose and genetic polymorphisms on BP metabolism and on extrapyramidal symptoms (EPS). The T max (3.9 ± 0.9 h), clearance (1.37 ± 0.52 ml/h/kg), and t 1/2 (20.4 ± 3.7 h) obtained in our study are comparable to those in previous Caucasian studies, although pharmacokinetic profiles were affected by the BP dose. We could not prove any significant correlations between BP metabolism or adverse effects and genetic factors because the number of subjects was small. Further studies with a larger population are needed to determine the influence of genetic factors on BP therapy. Copyright © 2006 John Wiley & Sons, Ltd.