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ALDH2 genotype‐associated differences in the acute effects of alcohol on P300, psychomotor performance, and subjective response in healthy young Korean men: a double‐blind placebo‐controlled crossover study
Author(s) -
Shin HeeYoung,
Shin IlSeon,
Yoon JinSang
Publication year - 2006
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.755
Subject(s) - aldh2 , psychomotor learning , placebo , crossover study , ingestion , psychology , alcohol , audiology , medicine , aldehyde dehydrogenase , physiology , psychiatry , cognition , genetics , biology , alternative medicine , pathology , gene , biochemistry
Background This study investigated the acute effects of alcohol on neurophysiological and psychomotor functions and the subjective response in healthy young Korean men according to the mitochondrial aldehyde dehydrogenase (ALDH2) genotype. Method A total of 24 males, half with ALDH2*1/*1 (active form) and the rest with ALDH2*1/*2 (inactive form), were selected through genotyping. In a double‐blind placebo‐controlled crossover design, each subject consumed either a 0.5 g/kg dose of alcohol or a placebo on two separate occasions, 1 week apart. The blood alcohol concentrations (BACs), P300 of event‐related potential, psychomotor performance, and perceived feelings were assessed. Results Although the BACs were similar between the two groups, the effects of alcohol on P300 were greater overall in subjects with ALDH2*1/*2 than in subjects with ALDH2*1/*1. Psychomotor performance was more impaired after alcohol ingestion in subjects with ALDH2*1/*2 than in subjects with ALDH2*1/*1. The subjective response after alcohol ingestion was more negative in subjects with ALDH2*1/*2, compared to subjects with ALDH2*1/*1. Conclusions These results suggest that the ALDH2 polymorphism is an important factor in determining the effects of alcohol on various psychobehavioral functions. Copyright © 2006 John Wiley & Sons, Ltd.