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Onset of antidepressant action: a pharmacological question?
Author(s) -
Rojo J. E.,
Gibert K.,
Cobo J.,
RodriguezCano E.,
Vallejo J.
Publication year - 2005
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.708
Subject(s) - mirtazapine , antidepressant , onset of action , clinical global impression , depression (economics) , medicine , rating scale , logistic regression , psychology , placebo , developmental psychology , alternative medicine , macroeconomics , pathology , hippocampus , economics
Objective This study was conducted to analyse the onset of action of antidepressants in naturalistic conditions. Method Multicenter, prospective, open‐label, non‐comparative naturalistic study among 582 depressed outpatients treated with mirtazapine. The patients were assessed at screening, and after 1, 2 and 4 weeks by the 17‐item Hamilton depression rating scale (17‐HAM‐D) and clinical global impression (CGI). Onset of action was measured by traditional analyses based on the time to a persistent reduction of more than 50% from baseline on the 17‐HAM‐D. Patients were grouped into four groups: very fast responders, fast responders, traditional responders and partial or non‐responders. The non‐parametric Kruskall–Wallis test was used to assess differences between the groups and logistic regression to predict response after 1 week of treatment. Results 16% of patients had a very fast response, 42.1% a fast response, 26.5% a traditional response and 15.5% a partial or non‐response. There were no significant differences between these groups with regard to dose of mirtazapine or sociodemographic characteristics. The baseline total 17‐HAM‐D was lower in the faster groups than in the slower groups. The evolution of 17‐HAM‐D items was similar in each responder group. Conclusion Time to response varied from early faster response to late slower response. The evolution of 17‐HAM‐D for each type of response was similar, but occurred at a different time in each group. Copyright © 2005 John Wiley & Sons, Ltd.