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The effect of quetiapine on aggression and hostility in patients with schizophrenia
Author(s) -
Arango Celso,
Bernardo Miguel
Publication year - 2005
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.686
Subject(s) - hostility , quetiapine , placebo , aggression , schizophrenia (object oriented programming) , psychology , clinical psychology , psychiatry , path analysis (statistics) , sedation , medicine , anesthesia , statistics , alternative medicine , mathematics , pathology
A post hoc analysis of data from three placebo‐controlled, double‐blind, randomized trials was carried out to determine the efficacy of quetiapine in aggression and hostility in patients with schizophrenia. Quetiapine treatment induced statistically significantly greater improvements in BPRS positive symptom cluster scores and three measures of hostility derived from the BPRS, compared with placebo, in patients symptomatic at baseline. A path analysis showed that the improvements in hostility were highly correlated with improvements in positive symptoms and there was no consistent relationship between sedation and hostility. Aggressive behaviour appears to be related to positive symptoms of schizophrenia. Quetiapine may be a suitable option for patients with schizophrenia and aggressive behaviour. Copyright © 2005 John Wiley & Sons, Ltd.