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Liverpool University Neuroleptic Side‐Effect Rating Scale (LUNSERS) as a subjective measure of drug‐induced parkinsonism and akathisia
Author(s) -
Jung HeeYeon,
Kim JongHoon,
Ahn YongMin,
Kim SeongChan,
Hwang Samuel S.,
Kim YongSik
Publication year - 2005
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.655
Subject(s) - akathisia , parkinsonism , rating scale , psychology , side effect (computer science) , olanzapine , extrapyramidal symptoms , psychiatry , clinical psychology , schizophrenia (object oriented programming) , medicine , antipsychotic , developmental psychology , disease , computer science , programming language
The Liverpool University Neuroleptic Side‐Effect Rating Scale (LUNSERS) was examined for its usefulness as a subjective measure of drug‐induced parkinsonism and akathisia. Eighty‐three subjects were assessed using the LUNSERS, the Simpson–Angus Scale (SAS) and the Barnes Akathisia Rating Scale (BARS), before and after a 6‐week treatment with olanzapine. Significant correlations were found between the changes in scores of parkinsonism items of LUNSERS and SAS. The changes in scores of akathisia item (restlessness), extrapyramidal side effects (EPS) subscale and psychic side‐effects subscale of LUNSERS were significantly correlated with those of the BARS. ‘Shakiness’, one item of the EPS subscale of LUNSERS, correctly classified between parkinsonism and non‐parkinsonism groups with 81.0% accuracy. A combination of four items included in EPS and psychic side‐effect subscales of LUNSERS identified akathisia and non‐akathisia groups with 76.2% accuracy. These results suggest that the EPS and psychic side‐effect subscales of LUNSERS may be useful in screening for drug‐induced parkinsonism and akathisia. Copyright © 2004 John Wiley & Sons, Ltd.