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Combination of mood stabilizers with quetiapine for treatment of acute bipolar disorder: an open label study
Author(s) -
Bahk WonMyong,
Yoon BoHyun,
Lee KyoungUk,
Chae JeongHo
Publication year - 2004
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.577
Subject(s) - young mania rating scale , quetiapine , mania , brief psychiatric rating scale , clinical global impression , bipolar disorder , psychology , rating scale , psychiatry , quetiapine fumarate , mood , bipolar i disorder , bipolar ii disorder , medicine , placebo , psychosis , atypical antipsychotic , schizophrenia (object oriented programming) , antipsychotic , developmental psychology , alternative medicine , pathology
Objectives The atypical antipsychotics are being increasingly used to control acute manic episodes, and data are emerging to support their mood‐stabilizing and antidepressant properties. This study investigated the short‐term efficacy of quetiapine as an add‐on therapy in the treatment of acute mania. Method This study was a 4‐week, open‐label, add‐on, prospective investigation using quetiapine in addition to mood stabilizers. Data on 18 patients fulfilling DSM‐IV diagnostic criteria for bipolar I disorder were analysed. The Young mania rating scale (YMRS), the Hamilton scale for depression (HDRS), the brief psychiatric rating scale (BPRS) and extrapyramidal symptom rating scale (ESRS) were applied at baseline and at weeks 1, 2 and 4. The clinical global impression scale (CGI) was evaluated at baseline and week 4. Results The addition of quetiapine produced a statistically significant improvement on the YMRS, HDRS, BPRS and CGI score at week 4 from baseline ( p <0.005). Quetiapine was well tolerated, with no subjects discontinuing because of side effects. Conclusions The combination of quetiapine was associated with a substantial symptomatic improvement in patients with acute mania. Randomized placebo‐controlled prospective studies are needed. Copyright © 2004 John Wiley & Sons, Ltd.