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Reduced short‐term obsessive–compulsive symptoms in schizophrenic patients treated with risperidone: a single‐blind prospective study
Author(s) -
Veznedaroglu Baybars,
Ercan Eyup Sabri,
Kayahan Bulent,
Varan Azmi,
Bayraktar Erhan
Publication year - 2003
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.536
Subject(s) - risperidone , term (time) , single blind , medicine , psychology , obsessive compulsive , prospective cohort study , schizophrenia (object oriented programming) , psychiatry , clinical psychology , randomized controlled trial , physics , quantum mechanics
Background Risperidone is a widely used agent as first‐line treatment in schizophrenia with a favorable side‐effect profile. However, a number of case reports have suggested an increase in obsessive–compulsive symptoms in patients treated with risperidone. Objective The aim of this study was to investigate the effect of risperidone on obsessive–compulsive symptoms in the treatment of schizophrenia. Method Forty patients with DSM‐IV diagnosis of schizophrenia were included in the study. The Yale‐Brown obsessive compulsive scale was administered before, at the end of first and second months of treatment. Paired‐samples t ‐test was used to compare the three assessments. Results There was not an increase, but a significant decrease, in YBOCS scores over time during risperidone treatment ( p <0.05). Conclusion In the present study risperidone caused a significant decrease in obsessive–compulsive symptoms in the treatment of schizophrenia. Copyright © 2003 John Wiley & Sons, Ltd.