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Olanzapine induced neuroleptic malignant syndrome—a case review
Author(s) -
Kogoj Aleš,
Velikonja Ingrid
Publication year - 2003
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.483
Subject(s) - neuroleptic malignant syndrome , olanzapine , clozapine , medicine , antipsychotic , pediatrics , psychiatry , schizophrenia (object oriented programming)
Neuroleptic malignant syndrome is the rarest and the most serious of the neuroleptic induced movement disorders. Although potent neuroleptics are more frequently associated with NMS, atypical antipsychotic drugs may also be a cause of NMS. Three databases were searched using the terms ‘ olanzapine ’ and ‘ neuroleptic ’ ‘ malignant syndrome ’. Case reports were selected and reviewed from among all articles that fulfilled the search criteria. Twenty six cases were reviewed. Twenty cases fulfilled the criteria published by Sachdev et al . Olanzapine was the most probable cause of NMS in 16 cases. The absence of rigidity was described in only two of 16 highly probable olanzapine induced NMS cases, which is not as often as it is reported in clozapine associated NMS (36%). It was found that prior NMS is an important risk factor in NMS. Copyright © 2003 John Wiley & Sons, Ltd.