Premium
Zotepine in Huntington's disease
Author(s) -
Bonelli Raphael M.,
Niederwieser Gerald,
Lahousen Theresa,
Hofmann Peter
Publication year - 2003
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.474
Subject(s) - chorea , huntington's disease , rating scale , physical medicine and rehabilitation , motor function , medicine , disease , psychology , physical therapy , developmental psychology
The authors report a patient with Huntington's disease (HD) presenting with severe chorea. The motor scale of the unified HD rating scale (UHDRS‐I) revealed 81 points. Motor function clearly improved with zotepine, until she reached an UHDRS‐I of 34 points on day 7 of treatment. The patient was stable for at least 12 weeks. The improvement includes all seven categories of the UHDRS‐I, especially chorea, gait and oral function. This is the first description of zotepine in HD. Our findings suggest that zotepine is useful in the treatment of HD chorea. Controlled trials of its use in HD would be welcome. Copyright © 2003 John Wiley & Sons, Ltd.