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Crossover reaction between mianserin and trazodone for restless legs syndrome
Author(s) -
Otani Koichi,
Kaneko Sunao
Publication year - 1995
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470100610
Subject(s) - mianserin , trazodone , restless legs syndrome , nortriptyline , imipramine , medicine , pathophysiology , anesthesia , antidepressant , pharmacology , amitriptyline , insomnia , pathology , alternative medicine , hippocampus
A 58‐year‐old woman with a past history of mianserin‐induced restless legs syndrome (RLS) developed the same syndrome on subtherapeutic doses of trazodone. However, neither nortriptyline nor imipramine at therapeutic doses caused RLS. The present report suggests that hyposerotonergic states are involved in the pathophysiology of RLS.