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[ 3 H]Imipramine binding in type I and type II alcoholism
Author(s) -
Patkar A. A.,
Naik P. C.,
Mardsen C. A.,
McKlean P. C.,
Kendall D. A.,
AlChalabi T.
Publication year - 1995
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470100410
Subject(s) - imipramine , abstinence , alcohol , alcohol dependence , medicine , psychology , psychiatry , chemistry , endocrinology , pharmacology , biochemistry , pathology , alternative medicine
Abstract Platelet [ 3 H]‐imipramine binding was measured in 29 male alcohol dependents (DSM III‐R) serially over 14 days of withdrawal. 29 male abstainers and 20 healthy volunteers. [ 3 H]‐Imipramine binding was significantly greater in alcohol dependents and abstainers when compared with controls. On further grouping, type II alcoholism was specifically associated with the raised imipramine binding and this occurred irrespective of the duration or severity of drinking or the length of abstinence. The result indicates that platelet [ 3 H]‐imipramine binding could be a biological marker of type II alcoholism.