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Enhanced blockade of 45 Ca 2+ uptake into platelets in manic patients with bipolar affective disorder with flunarazine and verapamil
Author(s) -
Berk Michael,
Kirchmann Nicola Helen
Publication year - 1995
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470100407
Subject(s) - verapamil , bipolar disorder , platelet , blockade , lithium (medication) , chemistry , radiochemistry , psychiatry , psychology , calcium , medicine , receptor
This study examined bipolar patients in the manic and depressed phases of bipolar disorder and controls, measuring basal radiolabelled 45 Ca 2+ uptake into platelets, and the effects of verapamil and fluanarazine on uptake. Radiolabelled 45 Ca 2+ uptake into platelets was measured in the manic ( N = 13) and depressed ( N = 15) phases of bipolar disorder compared to controls ( N = 13) using a β liquid scintillation counter. Both flunarazine ( p = 0·0196) and verapamil ( p = 0·0486) caused greater inhibition of 45 Ca 2+ uptake in manics than controls. Flunarazine ( p = 0·0209) was also associated with greater inhibition of calcium uptake in manics than depressives. Flunarazine and verapamil enhance the blockade of 45 Ca 2+ uptake into platelets in manic patients with Bipolar Affective Disorder.