Enhanced blockade of  45 Ca 2+  uptake into platelets in manic patients with bipolar affective disorder with flunarazine and verapamil | Zendy

Berk Michael | Zendy; Kirchmann Nicola Helen | Zendy

Premium

Enhanced blockade of 45 Ca 2+ uptake into platelets in manic patients with bipolar affective disorder with flunarazine and verapamil

Author(s) -

Berk Michael,

Kirchmann Nicola Helen

Publication year - 1995

Publication title -

human psychopharmacology: clinical and experimental

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.461

H-Index - 78

eISSN - 1099-1077

pISSN - 0885-6222

DOI - 10.1002/hup.470100407

Subject(s) - verapamil , bipolar disorder , platelet , blockade , lithium (medication) , chemistry , radiochemistry , psychiatry , psychology , calcium , medicine , receptor

This study examined bipolar patients in the manic and depressed phases of bipolar disorder and controls, measuring basal radiolabelled 45 Ca 2+ uptake into platelets, and the effects of verapamil and fluanarazine on uptake. Radiolabelled 45 Ca 2+ uptake into platelets was measured in the manic ( N = 13) and depressed ( N = 15) phases of bipolar disorder compared to controls ( N = 13) using a β liquid scintillation counter. Both flunarazine ( p = 0·0196) and verapamil ( p = 0·0486) caused greater inhibition of 45 Ca 2+ uptake in manics than controls. Flunarazine ( p = 0·0209) was also associated with greater inhibition of calcium uptake in manics than depressives. Flunarazine and verapamil enhance the blockade of 45 Ca 2+ uptake into platelets in manic patients with Bipolar Affective Disorder.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research