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Aerophagia: A neuroleptic‐associated tardive syndrome?
Author(s) -
Hayashi Teruo,
Nishikawa Tadashi,
Kado Kazuo,
Koga Itsuyuki,
Uchida Yasunori,
Yamawaki Shigeto
Publication year - 1995
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470100311
Subject(s) - tardive dyskinesia , medicine , achalasia , dyskinesia , anesthesia , schizophrenia (object oriented programming) , esophagus , psychiatry , disease , parkinson's disease
Some cases suggestive of a tardive dyskinesia (TD)‐induced esophageal movement disorder have been reported. We represent a patient with severe orofacial dyskinesia, an oesophageal movement disorder, and aerophagia following long‐term neuroleptic treatment. This 40‐year‐old mentally retarded man showed signs of oral dyskinesia over 20 years ago, with extension to his limbs and trunk within the last 5 years. He also demonstrated noisy air gulping every several seconds. An abdominal radiograph revealed a big magenblase and dilatated, air‐filled segments of large and small intestine without a niveaus. Oesophageal contrastradiography revealed evidence of an oral dyskinesia involving the esophageal musculature and a dilated oesophagus (maximal width: 4·5 cm). Although the oesophageal dilatation was similar to that in patients with a spindle type of achalasia, the oesophageal‐cardio junction was sometimes open completely, differing from conditions associated with achalasia. A polygraphic study revealed frequent high‐amplitude bursts of microvibration, concurrent with the gulping. The signs of aerophagia and laryngeal dyskinesia decreased 6 days following clonazepam administration. Thus, we suggested that tardive dyskinesia is associated with the laryngeal and oesophageal‐induced aerophagia. This is the first report of aerophagia associated with neuroleptic‐induced tardive syndrome.