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Lithium and anticholinergic combination to maintain a stable lithium plasma level
Author(s) -
Bellibas S. Eralp,
Ülker Sibel,
Akfert Kazim,
Tuglular Isik,
Vahip Simavi
Publication year - 1994
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470090104
Subject(s) - anticholinergic , lithium (medication) , plasma levels , medicine , endocrinology , pharmacology , anesthesia
The effect of lithium and propantheline, an anticholinergic agent, combination on plasma and red blood cell (RBC) lithium levels was studied to test if this combination could maintain a stable plasma lithium level for a long‐lasting period by delaying gastric emptying, in rabbits. There was a significant difference in plasma lithium levels between control and propantheline‐administered groups ( p < 0·01). The peak level seen in the second hour of lithium administration in the control group was not observed in the propantheline‐administered group and a stable lithium level was maintained. It was suggested that a lithium and anticholinergic drug combination can be an alternative in eliminating the peak plasma levels of lithium and preventing the side‐effects thought to be related to this factor.