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Prolactin response to zotepine in schizophrenic patients
Author(s) -
Otani Koichi,
Kondo Tsuyoshi,
Ishida Masayuki,
Sasa Hiroshi,
Higuchi Hisashi,
Kaneko Sunao,
Fukushima Yutaka
Publication year - 1993
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470080107
Subject(s) - prolactin , medicine , endocrinology , dopamine , antipsychotic , pharmacology , agonist , dopamine agonist , antipsychotic drug , chemistry , schizophrenia (object oriented programming) , hormone , receptor , psychiatry , dopaminergic
The prolactin response to an antipsychotic drug zotepine, which has both antidopaminergic and antiserotonergic effects, was studied in 24 inpatients suffering from schizophrenia. The daily dose was 100 mg in the first week, and 200 mg for the next three weeks. The mean serum concentrations of prolactin at the daily dose of 200 mg, but not 100 mg, were significantly higher than that before treatment. The δ prolactin (the change from the pretreatment concentration) was significantly correlated with zotepine concentrations at each week. At low zotepine concentrations, patients with high pre‐treatment prolactin concentrations showed negative δ prolactin. The present study thus suggests that at high concentrations zotepine shows predominantly antidopaminergic effects, while at low concentrations its antiserotonergic effects are predominant and/or it acts as a dopamine agonist.