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Effects of mood‐stabilizing drugs on the peripheral serotonin transporter
Author(s) -
Marazziti D.,
Rotondo A.,
Lenzi A.,
Presta S.,
Silvestri S.,
Cassano G. B.
Publication year - 1992
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470070605
Subject(s) - carbamazepine , imipramine , pharmacology , clomipramine , chemistry , serotonin transporter , valproic acid , serotonin , verapamil , nifedipine , lithium (medication) , transporter , endocrinology , medicine , biochemistry , epilepsy , receptor , calcium , psychiatry , alternative medicine , organic chemistry , pathology , gene
We studied the effect of lithium (L), carbamazepine (CBZ), valproic acid (VA), verapamil (VP) and nifedipine (NF) on the specific binding of 3 H‐imipramine ( 3 H‐IMI) to platelet membranes, as compared with clomipramine (CLO). The results showed that VP, NF and CLO exerted a concentration‐dependent inhibition on the IMI binding; CLO had the most potent inhibitory effect. No effect was observed with L. CBZ or VA. These results suggest that while VP and NF interact with the 5‐HT transporter complex, L, CBZ and VA do not. Therefore, their effective (or suggested) mood‐stabilizing effects are likely to be related to different mechanisms.